SUMMARY OF THE ROLE
You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization. 
You will partner with project teams to enable data-driven decisions that advance programs from discovery toward translation.
You will help shape study plans, and ensure timely delivery of milestones across functions.

ROLE & RESPONSIBILITIES
•    Study Design and Execution: Design and run in vitro studies for CAR T candidates; design constructs and characterize engineered cell therapies; develop, execute, and optimize functional assays.
•    Data analysis and reporting: Analysis data, generate figures, and prepare reports and slide decks, present results and propose next experiment steps.
•    Quality and compliance: Ensure adherence to required training and maintain accurate, complete experimental records. 
•    Cross-functional collaboration: Align with Pharmacology & Toxicology, CMC, translational science and clinical teams to advance project.
•    Team and communication: Clear scientific writing and presentation, mentor colleagues and foster a productive, well-organized lab environment
•    Problem-Solving: Track record of trouble shooting models, optimizing protocols, and meeting timelines in a dynamic environment.

REQUIREMENTS
Education: PhD in immunology, cell biology, or related field; or MS with 4+ years demonstrated impact in cell therapy discovery

Skills & Capabilities
•    Primary Cell Culture: Proficient in human primary cell isolation, culture, activation, and maintenance.
•    Prepare lentiviral vectors and perform transduction; optimize MOI to maximize transduction efficiency; assess vector copy number and integration characteristics; conduct electroporation-based gene edits.
•    Flow cytometry: Proficient in panel design, compensation, and gating.
•    Functional assays: target killing (luciferase/impedance), cytokines, proliferation/persistence, serial-kill or rechallenge assays; antigen density titration and specificity testing.
•    Molecular methods: PCR/qPCR, plasmid prep; amplicon NGS prep for edit verification and transgene integrity.
•    Data & Tools: Proficiency with ELN, FlowJo, Snapgene, GraphPad; understanding of assay acceptance criteria and basic statistics.
•    Compliance: Practice BSL 2 biosafety, uphold animal ethics (IACUC), maintain awareness of research GxP, and ensure data integrity.
Preferred Experience:
•    Program Advancement: Progress CAR T candidates from lead optimization to preclinical packages; support method transfer and qualification with Process Development.
•    Advanced Modalities: Experience with armored CARs, logic gated CARs.